An open EAR for polycomb repressive complexes

Molecular architecture of polycomb repressive complexes

The polycomb group (PcG) proteins are a large and diverse family that epigenetically repress the transcription of key developmental genes. They form three broad groups of polycomb repressive complexes (PRCs) known as PRC1, PRC2 and Polycomb Repressive DeUBiquitinase, each of which modifies and/or remodels chromatin by distinct mechanisms that are tuned by having variable compositions of core an...

Concerted Divergence after Gene Duplication in Polycomb Repressive Complexes.

Duplicated genes are a major contributor to genome evolution and phenotypic novelty. There are multiple possible evolutionary fates of duplicated genes. Here, we provide an example of concerted divergence of simultaneously duplicated genes whose products function in the same complex. We studied POLYCOMB REPRESSIVE COMPLEX2 (PRC2) in Brassicaceae. The VERNALIZATION (VRN)-PRC2 complex contains VR...

Huntingtin Facilitates Polycomb Repressive Complex

Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma Implications for Biology and Therapy

Alzrigat, M. 2017. Targeted Inhibition of Polycomb Repressive Complexes in Multiple Myeloma. Implications for Biology and Therapy. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1296. 53 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9805-4. Multiple myeloma (MM) is a hematological malignancy of antibody producing plasmablasts/ plasma cells. ...

Huntingtin facilitates polycomb repressive complex 2

Huntington's disease (HD) is caused by expansion of the polymorphic polyglutamine segment in the huntingtin protein. Full-length huntingtin is thought to be a predominant HEAT repeat alpha-solenoid, implying a role as a facilitator of macromolecular complexes. Here we have investigated huntingtin's domain structure and potential intersection with epigenetic silencer polycomb repressive complex ...